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           Factor XIII is the last clotting factor involved in the clotting process.

Factor XIII in plasma exists as a tetramer (A2B2), including two A and two B subunits. The A subunit is the catalytic subunit, and the B subunit is connected to the A2 dimer as a monomer. The B subunit acts as a carrier to protect the A subunit from degradation, promote the affinity of the A subunit and fibrin, and regulate the A subunit’s protease activity. Under the action of Ca2+, the factor XIII tetramer is reversibly dissociated into dimers, but A2 still has no enzymatic activity at this time, and conformational changes will occur under the cleavage of thrombin and the continued action of Ca2+, exposing the sulfhydryl active center to activate.

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Note: 1. Storage principle: It can be stored at 2-8°C, avoiding exposure to sunlight. 2. Recommendation: Long-term storage: Store at -20°C. If it converts to dark yellow, waste it.